• Rev Med Interne · Nov 2024

    Review

    JAK inhibitors (JAKi): Mechanisms of action and perspectives in systemic and autoimmune diseases.

    • Liticia Chikhoune, Claire Poggi, Julie Moreau, Sylvain Dubucquoi, Eric Hachulla, Aurore Collet, and David Launay.
    • CHU de Lille, Service de Médecine Interne et Immunologie Clinique, Centre de référence des Maladies Auto-Immunes et Auto-inflammatoires Systémiques rares de l'Adulte du Nord, Nord-Ouest, Méditerranée et Guadeloupe (CeRAINOM), 59000 Lille, France.
    • Rev Med Interne. 2024 Nov 15.

    AbstractJanus kinase (JAK) molecules are involved in important cellular activation pathways. Over the past decade, many targeted therapies have emerged, including the increasingly promising role of JAK inhibitors (JAKi) in the treatment of inflammatory and autoimmune diseases. The spectrum of use of these small molecules is increasingly broader. JAKi have been approved in several autoimmune diseases. Currently, four molecules (tofacitinib, baricitinib, upadacitinib and filgotinib) have been labeled for moderate to severe rheumatoid arthritis (RA) with failure or poor tolerance of one or more conventional disease-modifying antirheumatic drug (csDMARDS), or biologics (bDMARDS). JAKi are now also commonly used in other diseases such as psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. They have also shown promising results in clinical trials for the treatment of other autoimmune conditions. We present here their mechanisms of action, and the main data about JAKi use on systemic and autoimmune diseases.Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

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