• Jianglong Liao, Tao Wang, Wei Dong, Jingfan Yang, Jun Zhang, Lvyu Li, Jiankun Chen, Jian Li, Deguang Li, Yunxi Ma, Xiaoyan Zhang, Xiaoxia Tang, Bo Jiang, and Ying Guo.
• Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, Yunnan, China.
• Medicine (Baltimore). 2019 Jul 1; 98 (29): e16478e16478.

ObjectiveThe aim of this study was to evaluate the effect of acupuncture injection therapy for the patients with nonspecific chronic low back pain (CLBP) systematically.MethodsFour English online databases and 4 Chinese online databases will be researched systematically from their inception to December 31, 2018. Reference management software, Endnote X7, will be used to manage and screen the records. After removing the duplicate records, 2 independent reviewers will select the studies that meet the inclusion criteria. "Risk of table" recommend by Cochrane Handbook for Systematic Reviews of Interventions will be used to judge the quality of the included records. All data will be extracted by 1 reviewer and checked by another reviewer. Any disagree will be addressed via consulting a third reviewer in the above processes. Microsoft Excel will be used to manage and convert data if necessary. The missing data will be obtained via emailing the original authors of included studies. Review Manager (RevMan5.3) will be used to perform the data synthesis if enough data were collected. Otherwise, only the qualitative analysis will be performed. Based on the heterogeneity results, fixed-effect model or random-effect model will be used to estimate the overall effect of acupuncture injection therapy for patients with nonspecific CLBP. Meta-regression and subgroup analysis will be also performed to explore the sources of heterogeneity. If there are enough records included, the publish bias will be assessed by funnel plot. All procedures will be strictly performed in accordance with the Cochrane Handbook for Systematic Reviews of Interventions.ConclusionThis review will offer clinical evidence of acupuncture injection therapy for the patients with nonspecific CLBP.Prospero Research Registration Identifying NumberCRD42019119158.

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