• Journal of neurotrauma · Jan 2004

    Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients.

    • Hülya Bayir, Donald W Marion, Ava M Puccio, Stephen R Wisniewski, Keri L Janesko, Robert S B Clark, and Patrick M Kochanek.
    • Safar Center for Resuscitation Research, and Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA.
    • J. Neurotrauma. 2004 Jan 1;21(1):1-8.

    AbstractStriking gender differences have been reported in the pathophysiology and outcome of acute neurological injury. Greater neuroprotection in females versus males may be due, in part, to direct and indirect sex hormone-mediated antioxidant mechanisms. Progesterone administration decreases brain levels of F(2)-isoprostane, a marker of lipid peroxidation, after experimental traumatic brain injury (TBI) in male rats, and estrogen is neuroprotective in experimental neurological injury. In this study, we evaluated the effect of gender on lipid peroxidation, as assessed by cerebrospinal fluid (CSF) levels of F(2)-isoprostane, after severe TBI in humans. Lipid peroxidation was assessed in CSF from 68 adults enrolled in two randomized controlled trials evaluating the effect of therapeutic hypothermia after severe TBI (Glasgow coma scale [GCS] score

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