• Xiao Li, Xin Yao, Jieying Wen, Qiaoling Chen, Ziming Zhu, Xinyue Zhang, Song Wang, Weixuan Lan, Yunsi Huang, Shanneng Tang, Xuan Zhou, Xuedong Han, and Tao Zhang.
• The graduate School of Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
• Medicine (Baltimore). 2024 Nov 15; 103 (46): e40513e40513.

AbstractTo examine the possible causative association between Crohn disease (CD) and the T-cell surface glycoprotein CD5 and to ascertain whether sphingomyelin (SM) functions as a mediator. We conducted a two-step Mendelian randomization (MR) study to further explore the pathogenesis of Crohn and its related targets. MR study was performed on CD5 and CD using summary-level data from a genome-wide association study. Additionally, by employing a two-step MR study method, we determined that SM might mediate the causal effect of CD5 on CD. There was a favorable correlation between the surface glycoprotein CD5 on T cells and vulnerability to CD, and SM mediated the causal effect of CD5 on CD (the mediating effect accounts for 9.2%). Our study revealed that CD5 and CD are causally related, with SM mediating a small fraction of the impact (approximately 9.2%). The mediating function of SM in the link between CD5 and CD is anticipated to be realized through the regulation of immune cell transportation, apoptosis of intestinal barrier cells, and maintenance of the intestinal microenvironment.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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