• Medicine · Nov 2024

    Meta Analysis

    Effects of the umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis: A systematic review and meta-analysis.

    • Zhijian Xiao, Xinying Wang, Cheng Li, Lihua Luo, and Wei Li.
    • Hangzhou Fuyang Hospital of TCM Orthopedics and Traumtology, Hangzhou, China.
    • Medicine (Baltimore). 2024 Nov 15; 103 (46): e40490e40490.

    BackgroundThis study aimed to evaluate the effects of umbilical cord mesenchymal stem cells (UC-MSCs) in the treatment of knee osteoarthritis.MethodsPubMed, Web of Science, Cochrane Library, Embase, Chinese National Knowledge Infrastructure and Wanfang databases were searched from inception to March 31, 2024. RevMan 5.3 was used to conduct meta-analyses of the final included studies.ResultsThree randomized controlled studies were conducted. Western Ontario and McMaster Universities Osteoarthritis Index was reduced in the UC-MSCs group compared that in to the control group (mean difference: -25.85; 95% confidence interval: -41.50, -10.20; P = .001). Knee Lysholm Score was improved in the UC-MSCs group compared with the control group (mean difference: 18.33; 95% confidence interval: 12.89, 23.77; P < .00001). Egger test showed P = .583, indicating no publication bias. Sensitivity analysis indicated that the results were stable.ConclusionIntra-articular injection of UC-MSCs improved function and reduced pain in patients with knee osteoarthritis. However, the number of included studies was small and more studies are needed to confirm this.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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