• Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi · Sep 2000

    [Modulation of nerve growth factor on wound healing of burn].

    • G Z Lü, Y L Chen, and M J Yang.
    • Department of Burn Surgery, Wuxi No. 3 People's Hospital, Wuxi Jiangshu, P. R. China 214041.
    • Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2000 Sep 1;14(5):268-70.

    ObjectiveTo investigate the effect of nerve growth factor(NGF) on the burn wound healing and to study the mechanism of burn wound healing.MethodsSix domestic pigs weighting around 20 kg were used as experimental animals. Twenty-four burn wound, each 2.5 cm in diameter, were induced on every pigs by scalding. Three different concentrations of NGF, 1 microgram/ml, 2.5 micrograms/ml, 5 micrograms/ml were topically applied after thermal injury, and saline solution used as control group. Biopsy specimens were taken at 3, 5 and 9 days following treatment and immunohistochemistry method was used to detect the epidermal growth factor(EGF), EGF receptor (EGF-R), NGF, NGF receptor (NGF-R), NGF, NGF-R, CD68 and CD3.ResultsThe expression of EGF, EGF-R, NGF, NGF-R CD68 and CD3 were observed in the experimental group, especially at 5 and 9 days, no expression of those six items in the control group.ConclusionNGF can not only act directly on burn wound, but also modulate other growth factors on the burn wound to accelerate the healing of burn wound.

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