• Internal medicine · Nov 2024

    Positive Antiganglioside Antibodies in a Patient with Primary Diffuse Large B-cell Lymphoma of the Central Nervous System.

    • Ryoji Nishi, Haruki Koike, Tomoya Maekawa, Yoshitaka Nakamura, Yohei Kawade, Takashi Tsujiuchi, Masasuke Ohno, Yuki Fukami, Masahisa Katsuno, and Takafumi Sagisaka.
    • Department of Neurology, Daido Hospital, Japan.
    • Intern. Med. 2024 Nov 21.

    AbstractUp to one-third of lymphoma cases involve the nervous system. Miller-Fisher syndrome (MFS) associated with lymphoma is extremely rare. We herein report a case of primary central nervous system lymphoma initially mimicking MFS in a 70-year-old man who presented with subacute unsteady gait and diplopia. A neurological examination revealed unilateral ophthalmoplegia, ataxia, and areflexia. The patient tested positive for anti-GQ1b antibodies, so MFS was initially suspected. However, the progression extended over one month. Subsequently, disturbance of consciousness was observed. Cranial magnetic resonance imaging revealed lesions in the periventricular fourth ventricle, and a brain biopsy indicated diffuse large B-cell lymphoma.

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