• Angelika Witoslawska, Jennifer M T A Meessen, Mika Hilvo, Antti Jylhä, Faiez Zannad, Marianna Cerrato, Patrick Rossignol, Deborah Novelli, Kevin Duarte, Giovanni Targher, Roberto Latini, Nicolas Girerd, and Reijo Laaksonen.
• Finnish Cardiovascular Research Center, University of Tampere, Tampere, Finland.
• Eur. J. Clin. Invest. 2024 Nov 23: e14359e14359.

BackgroundCeramide and phosphatidylcholine lipids-based risk score (CERT2) has shown a strong prognostic value in predicting cardiovascular (CV) events in patients with ischemic heart disease. This study aimed to investigate the prognostic value of CERT2 risk score in patients with heart failure (HF).MethodsThe current study combines data for 4234 subjects from the COMMANDER-HF trial and 1227 subjects from the GISSI-HF trial, which enrolled patients with a history of HF. The CERT2 risk score was calculated for all the participants as previously described. The primary outcome was CV death, but all-cause death and major adverse CV events (three-point MACE) were analysed as well.ResultsAfter adjustment for established CV risk factors and potential confounders, patients with the highest CERT2 risk category remained at almost three-fold higher risk of CV death (COMMANDER-HF: HR 2.80, 95% CI 2.18-3.60, GISSI-HF: 2.84, 95% CI 1.70-4.74), all-cause death (COMMANDER-HF: HR 2.97, 95% CI 2.36-3.75, GISSI-HF: 2.83, 95% CI 1.83-4.38) and MACE (COMMANDER-HF: HR 2.73, 95% CI 2.20-3.38, GISSI-HF: 2.67, 95% CI 1.67-4.26) compared to those with the lowest CERT2 risk category.ConclusionsThe CERT2 risk score is strongly associated with an increased risk of CV death, all-cause death and MACE in patients with HF.© 2024 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

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