• Pengtao Li, Jiawei Zhai, Ting Liu, Mengyuan Guo, and Yuzhen Wang.
• Pengtao Li, Department of Reproductive Medicine, Baoding Maternal and Child Health Care Hospital, Baoding 071000, Hebei, China.
• Pak J Med Sci. 2024 Nov 1; 40 (10): 217021752170-2175.

ObjectiveTo compare the pregnancy outcome of the fresh cycle or freeze-thaw cycle embryo transfer of patients treated with a long follicular phase regimen and antagonist regimen, and explore the clinical therapeutic effect of the two regimens.MethodsThis was a retrospective study. The data of a total of 543 patients who underwent in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) or frozen-thawed embryo transfer (FET) in Baoding Maternal and Child Health Care Hospital from January 2020 to December 2022 were retrospectively analyzed in this study and were divided into four group to analyze the basic conditions, medication, laboratory indicators and clinical outcomes after embryo transfer of patients in each group.ResultsThe pregnancy rate and implantation rate in Groups A, B and C were higher than those in Group-D, and the differences were statistically significant (p<0.05). The difference in multiple pregnancy rate and abortion rate among groups was not statistically significant (p>0.05). The influencing factors of clinical pregnancy rate were identified by binary Logistic regression analysis. Advanced age was found to be a risk factor for improving the pregnancy rate, while the increase in the number of oocytes retrieved is a protective factor for improving the pregnancy rate. The differences were statistically significant (p<0.05).ConclusionThe antagonist regimen has a low dosage and short medication time and can achieve a high embryo utilization rate and blastula formation rate, saving time and cost for patients.Copyright: © Pakistan Journal of Medical Sciences.

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