• A Marengoni, E von Strauss, D Rizzuto, B Winblad, and L Fratiglioni.
• NVS Department, Aging Research Center, Karolinska Institutet, Stockholm, Sweden. alessandra.marengoni@ki.se
• J. Intern. Med. 2009 Feb 1; 265 (2): 288295288-95.

ObjectiveWe aimed to disentangle the effect of chronic multimorbidity and disability on 3-year functional decline and survival in the elderly.DesignProspective cohort study with a mean of follow-up of 2.8 years.SettingSwedish elderly persons from the Kungsholmen Project (1987-2000).SubjectsA total of 1099 subjects, 77-100 years old, living in the community and institutions.Main Outcome MeasurementsMedical diagnoses (based on clinical examination, drug use, medical records and blood tests), and functional assessment (according to Katz Index) at baseline were investigated in relation to functional decline and death occurring during follow-up.ResultsAt baseline, 12.1% of participants had disability, and 52.3% were affected by multimorbidity. During follow-up, 363 persons died and 85 worsened in functioning. The number of chronic conditions incrementally increased the risk of functional decline [hazard ratio (HR) increased from 1.5 in subjects with one disease to 6.2 in persons with 4+ diseases]. However, this was not the case for mortality, as the HR of death was the same for people with one disease as well as 4+ diseases (HR=2.3). Baseline disability had the highest impact on survival, independently of number of diseases [HR=8.1; 95% confidence interval (CI)=4.8-13.7 in subjects with one disease and HR=7.7; 95% CI=4.7-12.6 in those with 2+ diseases].ConclusionsIn the elderly subjects, chronic disability rather than multimorbidity emerged as the strongest negative prognostic factor for functionality and survival.

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