• Am. J. Med. · Dec 2024

    Review

    Creating New Proteins for Medical Therapeutics: Short title: Designing Therapeutic Proteins.

    • Edward J Goetzl.
    • Department of Medicine, University of California San Francisco Medical Center, San Francisco, CA. Electronic address: edward.goetzl@ucsf.edu.
    • Am. J. Med. 2024 Dec 2.

    AbstractRecent applications of artificial intelligence-derived methods of computational design have permitted de novo creation of proteins that do not exist in nature but have potent effects on human cells and organ systems. These rapid procedures also allow in one step protein modifications that optimize function, potency, stability, resistance to biodegradation, cellular and tissue distribution and biological half-time. Such proteins generated to date include cytokines, antibodies, inhibitors of cell death proteins and antagonists of extracellular receptors for growth factors and viruses. Newly designed proteins have broad medical diagnostic and therapeutic potentials, as well as the capacity to alter many normal activities of human cells.Copyright © 2024 Elsevier Inc. All rights reserved.

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