• Southern medical journal · May 1975

    Snuff dippers keratosis (snuff-induced leukoplakia).

    • C J Raque, R V Biondo, M G Keeran, W M Honeycutt, and G T Jansen.
    • South. Med. J. 1975 May 1; 68 (5): 565568565-8.

    AbstractPatients with chronic snuff-induced keratosis associated with mucosal ulcerations were treated with topically applied vitamin A acid. In each case, after a marked, local inflammatory response initially, topical vitamin A acid showed a definite beneficial effect in promoting healing and involution of the precancerous snuff-induced leukoplakic keratosis. In one patient there was distinct involution of the oral lesions with complete healing and restoration of a normal-appearing mucosa within five weeks after beginning of treatment. In four patients there was healing of superficial ulcerations and regression in the size of the luekoplakic lesions.

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