• Jin Liang, Cong He, Qianqian Yang, Haoran Chen, Youlang Zhou, Aidong Deng, and Gu Heng Wang.
• Department of Hand Surgery, Affiliated Hospital of Nantong University, Nantong 226001, PR China; Medical School of Nantong University, Nantong 226001, PR China.
• Injury. 2024 Dec 5; 56 (2): 112038112038.

AbstractRestoring motor function and preventing re-rupture and adhesion during Achilles tendon healing remain significant clinical challenges. Increasing evidence suggests that miRNA plays a crucial role in tendon healing and regeneration. The previously designed nanosphere hydrogel sustained-release system enables targeted, controlled release of drugs. In this study, we developed a version of this system loaded with miR-34a-5p for localized delivery to an acute Achilles tendon injury model. The results of the Achilles functional index and Catwalk behavior analysis in rats indicated that miR-34a-5p mimic promoted early recovery of motor function following Achilles tendon injury. Although gross observation suggested that the miR-34a-5p mimic group had a minimal inhibitory effect on the adhesion of Achilles tendon tissue, tension analysis demonstrated that it effectively increased the maximum tensile strength. Additionally, in vitro experiments showed that miR-34a-5p mimic could increase tendon cells proliferation and improve tendon cells viability. This study confirmed the efficacy of the miR-34a-5p nanosphere hydrogel sustained-release system in tendon injury repair, presenting it as a promising treatment strategy for clinical practice.Copyright © 2024. Published by Elsevier Ltd.

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