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- Matthieu Legrand, Ashish K Khanna, Marlies Ostermann, Yuki Kotani, Ricard Ferrer, Massimo Girardis, Marc Leone, Gennaro DePascale, Peter Pickkers, Pierre Tissieres, Filippo Annoni, Katarzyna Kotfis, Giovanni Landoni, Alexander Zarbock, Patrick M Wieruszewski, Daniel De Backer, Jean-Louis Vincent, and Rinaldo Bellomo.
- Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA, 94143, USA. Matthieu.Legrand@ucsf.edu.
- Crit Care. 2024 Nov 26; 28 (1): 389389.
AbstractDysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of exogenous angiotensin II as a new therapeutic agent. In this review, we report a multinational and multi-disciplinary expert panel discussion on the role and implications of RAAS modulation in sepsis and the use of exogenous angiotensin II. The panel proposed guidance regarding patient selection and treatment options with exogenous angiotensin II which should trigger further research.© 2024. The Author(s).
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