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Cochrane Db Syst Rev · Nov 2024
Molecular biomarkers for predicting complete response to preoperative chemoradiation in people with locally advanced rectal cancer.
- Penelope A De Lacavalerie, Sarah J Lord, Matthew J Morgan, Catherine E Caldon, and Maija Rj Kohonen-Corish.
- Cancer Theme, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
- Cochrane Db Syst Rev. 2024 Nov 29; 11 (11): CD014718CD014718.
AbstractThis is a protocol for a Cochrane Review (prognosis). The objectives are as follows: Primary objectives To identify and estimate the prognostic value of molecular biomarkers as predictors of pathological complete response to neoadjuvant chemoradiotherapy in people with locally advanced rectal cancer. summarises the review question in population, index prognostic factor, comparator prognostic factor(s), outcome, timing, and setting (PICOTS) format. [Table: see text] [Figure: see text] Secondary objectives To explore the following biomarker measurement, treatment, and study design factors as possible sources of heterogeneity in the association between the prognostic factor and pathological response: type of assay/measurement method, biomarker positivity criteria or cut-off point, chemotherapy regimen, and radiotherapy regimen.Copyright © 2024 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
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