• Prehosp Emerg Care · Dec 2024

    Smartphone-Enabled Point-of-Care Testing for Prehospital Stroke Diagnosis.

    • Paloma Menéndez-Valladares, Rosa M Delgado, David Núñez-Jurado, Lluis Sempere-Bordes, Anna Penalba, Leire Azurmendi, Claudio Parolo, Ana Barragán, Juan Antonio Cabezas, de Jesús GilCarmenCNeurovascular Research Group, Institute de Biomedicine of Seville, IBiS/Virgen Macarena University Hospital/CSIC/University of Seville, Seville, Spain., José Moreno, Rafael Canto Neguillo, Roberto Valverde de Moyano, José Luis García Garmendia, Mercedes García Murillo, Ismael Muñoz Martínez, Antonia Romero Hidalgo, Francisco Aranda Aguilar, Soledad Pérez Sánchez, Jean-Charles Sánchez, and Joan Montaner.
    • Neurovascular Research Group, Institute de Biomedicine of Seville, IBiS/Virgen Macarena University Hospital/CSIC/University of Seville, Seville, Spain.
    • Prehosp Emerg Care. 2024 Dec 12: 1101-10.

    ObjectivesThe objective of this study was to evaluate the feasibility of point-of-care testing (POCT) devices for N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement in prehospital settings, with the aim of improving the speed and accuracy of stroke diagnosis, thereby facilitating quicker and more effective patient care.MethodsPrehospital blood samples were collected from suspected stroke patients, and NT-proBNP levels were measured using a POCT device in ambulances and hospitals. Results from the NT-proBNP POCT and smartphone images were analyzed. Plasma samples underwent Elecsys proBNP II immunoassay after storage at -80ºC.ResultsA total of 121 suspected stroke patients were included in the study. The correlation between POCT measured by the POCT and immunoassay for NT-proBNP was strong (R = 0.926). Smartphone images also strongly correlated with POCT values at 10 min (R²=0.9716) and 15 min (R²=0.9405). Stability analysis of samples showed consistent NT-proBNP results and a high correlation (R = 0.907) was observed between plasma and whole blood samples for NT-proBNP POCT.ConclusionsThis study highlights the potential of NT-proBNP POCT devices in ambulances to expedite stroke diagnosis and management within 10 min. Smartphone integration further enhances efficiency, adding advancement in prehospital stroke management.

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