• Victor J Dzau, Melissa H Laitner, and Emily L Shambaugh.
• US National Academy of Medicine, Washington, DC, USA. Electronic address: vdzau@nas.edu.
• Lancet. 2024 Dec 7; 404 (10469): 237123792371-2379.

AbstractAs the beginning of the next US presidential administration approaches, the USA faces a series of complex challenges that threaten the health of the American people and the effectiveness and sustainability of their health and health-care systems. Taking office in January, 2025, the next administration will need to address myriad systems-level and public health challenges, including the long-term health impacts of COVID-19 and threat of future pandemics, negative effects of climate change on health, unaffordability and inefficiencies in health care, and resulting and long-standing disparities in health-care access and health outcomes. Without decisive policy action, population health is likely to stagnate or even deteriorate. We present five priority areas to guide US federal strategy in 2025 and beyond: improve public health and address health and social inequities; catalyse transformation towards a more effective, equitable health system; address crucial health issues such as climate change; advance artificial intelligence for health and health care; and strengthen responsible science and innovation. To achieve these goals, we suggest policy action items for federal stakeholders and emphasise the importance of social determinants of health, cross-sector collaboration, population health perspectives, and transformative partnerships. By prioritising these strategic imperatives, the incoming administration can set a plan towards a healthier, more resilient future for all Americans.Copyright © 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.

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