• Arthur Henrique Cunha-Volpato, Carlos Izaias Sartorão Neto, SilvaLuiz Fernando Ferraz daLFFDDepartment of Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: burns@usp.br., and Paulo Campos Carneiro.
• Diagcel Laboratory and Rede D'OR - São Luiz Pathology Laboratory, São Paulo, SP, Brazil.
• Clinics (Sao Paulo). 2025 Jan 1; 80: 100539100539.

IntroductionThe use of Hormone Dosage (HD) in Fine Needle Aspiration Biopsy (FNA) needle washout fluid, introduced in the 1990s, initially aimed at measuring Thyroglobulin (TG). Elevated TG concentration in an extrathyroidal cervical lesion suggests metastases of Well-Differentiated Thyroid Carcinomas (WDTC). Over the years, HD has evolved to incorporate Calcitonin (CT) and Parathormone (PTH), improving sensitivity and specificity in diverse clinical scenarios. Despite varying cutoffs in the literature, existing data underscore significant advancements in diagnostic accuracy.MethodsThis paper presents a case series of 762 cervical lesions with FNA cytology and HD in different cervical regions.ResultsIt was possible to establish the histogenesis of the lesion based on a combination of the FNA cytology and PTH HD findings, so PTH was useful to determine parathyroid origin in all regions, Thyroglobulin (TG) and PTH together provide insights on cell origin in difficult cases. Thyroglobulin (TG) dosage enhances the accuracy of detecting well-differentiated thyroid carcinomas. In post-thyroidectomy by bed lesions, dosages help to determine non-thyroid/parathyroid lesions.DiscussionThe case series and review underscore the valuable contribution of HD in fine-needle aspiration for the evaluation of cervical lesions. By integrating HD with cytological, ultrasound, and clinical data, clinicians can enhance the accuracy and specificity of FNA in diagnosing various cervical lesions, ultimately improving patient care and management.Copyright © 2024. Published by Elsevier España, S.L.U.

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