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- Masatoshi Yoshimoto, Eiko Hasegawa, Yuki Oba, Hiroki Mizuno, Shigekazu Kurihara, Noriko Inoue, Akinari Sekine, Kiho Tanaka, Masayuki Yamanouchi, Tatsuya Suwabe, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Yutaka Yamaguchi, Takehiko Wada, Naoki Sawa, and Yoshifumi Ubara.
- Nephrology Center and the Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Japan.
- Intern. Med. 2024 Dec 5.
AbstractWe herein report a 69-year-old man with acute kidney injury who required dialysis after receiving a combination of three drug-induced lymphocyte stimulation test-positive drugs. A kidney biopsy showed tubulointerstitial nephritis with severe eosinophilic infiltration and numerous granuloma formations. Acute eosinophilic granulomatous tubulointerstitial nephritis was diagnosed. Eosinophilic granulomatosis with polyangiitis was ruled out because there was no evidence of vasculitis or serum antineutrophilic cytoplasmic antibody and no history of allergy. No clinical findings were suggestive of sarcoidosis. Based on the above findings, the disease was considered to be induced by these three drugs. The renal function was normalized with glucocorticoid treatment.
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