• Yonsei medical journal · Dec 2024

    Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Sensorineural Hearing Loss in Community-Dwelling Adults: an NHANES Analysis.

    • Yang Yu, Zhi-Chao Yang, and Li-Xin Wang.
    • Department of Otorhinolaryngology-Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
    • Yonsei Med. J. 2024 Dec 1; 65 (12): 741751741-751.

    PurposeSensorineural hearing loss (SNHL) is prevalent among older adults in the United States. Recent studies suggest the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a potential marker for metabolic and cardiovascular conditions. Our research investigates the association between the TG/HDL-C ratio and SNHL using a comprehensive national dataset.Materials And MethodsThis cross-sectional study utilized the National Health and Nutrition Examination Survey (NHANES) data cycle 1999-2000, 2001-2002, 2003-2004, 2011-2012, and 2015-2016. Participants aged 50-69 years with complete audiometry and TG/HDL-C data were included. The outcome was the presence of SNHL, defined as an average hearing threshold >25 dB in the better ear. We employed multivariate logistic regression adjusted for demographics, smoking, noise exposure, and comorbidities to explore the association.ResultsA total of 1148 participants constituted the analytic sample, and 31.4% had SNHL. Compared to no SNHL, those with SNHL exhibited higher TG/HDL-C ratios (3.5 vs. 2.7). Elevated TG/HDL-C tertiles correlated with increased SNHL odds [tertile 2: adjusted odds ratio (aOR)=1.50, 95% confidence interval (CI): 0.97-2.32, p=0.069; tertile 3: aOR=1.64, 95% CI: 1.03-2.63, p=0.039]. The link was stronger in participants without diabetes or obesity, with significant predictive values for SNHL presence (area under the ROC curve=0.716 and 0.753, respectively).ConclusionA higher TG/HDL-C ratio was significantly associated with SNHL in US adults aged 50-69 years, especially in those free from diabetes or obesity. These findings support considering TG/HDL-C as a useful marker for SNHL risk, highlighting the importance of combined metabolic and auditory health assessments.© Copyright: Yonsei University College of Medicine 2024.

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