Promoting Prevention and Targeting Remission of Asthma A

Chest · Dec 2024

Review

Promoting Prevention and Targeting Remission of Asthma A EUFOREA Consensus Statement on Raising the Bar in Asthma Care.

Asthma is a common multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes/endotypes and the availability of targeted biologic treatment options, a substantial proportion of patients remains uncontrolled with risk of exacerbations, requiring systemic corticosteroids, and progressive disease. Current international guidelines advocate a personalized management approach to patients with uncontrolled severe asthma. ⋯ The EUFOREA asthma expert panel was convened to discuss strategies to optimize asthma care, prevent systemic corticosteroids overuse and disease progression. In this meeting report, we summarize current concepts and recommendations and provide a rationale to implement personalized asthma management at earlier stages of the disease. The ultimate goal is to move away from the current "one-size-fits-most" concept, which focuses on a symptom-driven treatment strategy, and shift towards a phenotype/endotype-targeted approach aimed at curbing the disease course by improving clinical outcomes and preserving health-related quality of life.

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- Milos Jesenak, Dr Anna Bobcakova, Ratko Djukanovic, Mina Gaga, Nicola A Hanania, Liam G Heaney, Ian Pavord, Santiago Quirce, Dr Dermot Ryan, Wytske Fokkens, Dr Diego Conti, Peter W Hellings, Glenis Scadding, Elizabeth Van Staeyen, Leif H Bjermer, and Zuzana Diamant.
- Department of Pediatrics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Teaching Hospital in Martin, Martin, Slovakia; Department of Pulmonology and Phthisiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Teaching Hospital in Martin, Martin, Slovakia; Institute of Clinical Immunology and Medical Genetics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Teaching Hospital in Martin, Martin, Slovakia.
- Chest. 2024 Dec 11.
Topic ImportanceAsthma is a common multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes/endotypes and the availability of targeted biologic treatment options, a substantial proportion of patients remains uncontrolled with risk of exacerbations, requiring systemic corticosteroids, and progressive disease. Current international guidelines advocate a personalized management approach to patients with uncontrolled severe asthma.Review FindingsThe EUFOREA asthma expert panel was convened to discuss strategies to optimize asthma care, prevent systemic corticosteroids overuse and disease progression. In this meeting report, we summarize current concepts and recommendations and provide a rationale to implement personalized asthma management at earlier stages of the disease. The ultimate goal is to move away from the current "one-size-fits-most" concept, which focuses on a symptom-driven treatment strategy, and shift towards a phenotype/endotype-targeted approach aimed at curbing the disease course by improving clinical outcomes and preserving health-related quality of life.Copyright © 2024. Published by Elsevier Inc.

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Promoting Prevention and Targeting Remission of Asthma A EUFOREA Consensus Statement on Raising the Bar in Asthma Care.

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