• Ratnesh Singh Kanwar, Kirtida Gambhir, Tanishka Aggarwal, Akash Godiwal, and Kuntal Bhadra.
• Division of Clinical Research and Medical Management (CRMM), Institute of Nuclear Medicine & Allied Sciences (INMAS), DRDO, Delhi 110054, India.
• Mil Med. 2024 Dec 5.

IntroductionAnthrax, caused by the bacterium Bacillus anthracis, stands as a formidable threat with both natural and bioterrorism-related implications. Its ability to afflict a wide range of hosts, including humans and animals, coupled with its potential use as a bioweapon, underscores the critical importance of understanding and advancing our capabilities to combat this infectious disease. In this context, exploring futuristic approaches becomes imperative, as they hold the promise of not only addressing current challenges but also ushering in a new era in anthrax management. This review delves into strategies to mitigate the impact of anthrax on global health and security, envisioning a future where our arsenal against anthrax is characterized by precision and adaptability.Materials And MethodsThis article highlights the significant potential of anthrax as a bioweapon, while also highlighting current knowledge and strategies developed against this deadly pathogen. We have performed an extensive research and literature review in concordance with the criteria outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A search strategy was conducted by using numerous keywords on various academic databases, yielding an initial set of 546 records along with 80 supplementary articles. The search included research papers, review papers, perspectives, clinical guidelines, and scientific blogs. The primary and secondary screening of the articles were conducted by 2 independent reviewers along with a third reviewer mitigating any discrepancies and biases encountered during the process. A set of inclusion and exclusion criteria were formulated, and a PICO framework was adapted based on which multiple records were analyzed and considered for the review.ResultsIn total, 53 articles were selected after completing a comprehensive systematic literature review. This review proposes novel approaches and scientific analysis of the complexities surrounding anthrax in the context of bioterrorism, highlighting the emerging technologies and strategies employed for bioterrorism mitigation.ConclusionsThe upcoming advancements in anthrax research will be based on cutting-edge technologies and innovative approaches that demonstrate great potential for prevention, detection, and treatment. These advancements may include the incorporation of synthetic biology techniques such as precise manipulation of biological components, nanoscale diagnostics, and Clustered regularly interspaced short palindromic repeats-based technologies, which could revolutionize our ability to combat anthrax on a molecular level. As these progressive methodologies continue to evolve, the integration of these technologies has the potential to redefine our strategies against anthrax, providing more accurate, personalized, and adaptable approaches to address the challenges posed by this infectious threat.© The Association of Military Surgeons of the United States 2024. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.

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