• Internal medicine · Dec 2024

    Anti-Tr/DNER Antibody-associated Paraneoplastic Neurological Syndrome Presenting Limbic Encephalitis with Anaplastic Large Cell Lymphoma: A Case Report.

    • Shintaro Fujii, Hiroaki Yaguchi, Ikuko Takahashi-Iwata, Takashi Inoue, Monami Tarisawa, Taichi Nomura, Akihiko Kudo, Hisashi Uwatoko, Shinichi Shirai, Masaaki Matsushima, Riku Miyaishi, Noriyuki Otsuka, Keiko Tanaka, Koji Taniguchi, Masato Takahashi, Shinya Tanaka, and Ichiro Yabe.
    • Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
    • Intern. Med. 2024 Dec 12.

    AbstractAn 82-year-old man presented with acute progressive disturbance of consciousness. We suspected autoimmune limbic encephalitis because of abnormal magnetic resonance imaging findings in the bilateral temporal lobes and cerebrospinal fluid pleocytosis. The patient tested positive for anti-Tr/Delta/Notch-like epidermal growth factor-related receptor (DNER) antibodies, and a tissue biopsy revealed complications of anaplastic large cell lymphoma. Typically, anti-Tr/DNER antibody-associated paraneoplastic neurological syndrome presents with cerebellar ataxia and is complicated by Hodgkin lymphoma (HL). However, there are rare cases that present only with LE and are complicated by tumors other than HL; therefore, aggressive antibody measurement and search for tumors are important.

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