• Anna Mary Jose, Aryan Rafieezadeh, Muhammad Zeeshan, Jordan Kirsch, Gabriel Froula, Kartik Prabhakaran, and Bardiya Zangbar.
• Westchester Medical Center, New York Medical College, Valhalla, NY, United States.
• Injury. 2024 Dec 3: 112076112076.

BackgroundHypothermia is known to contribute to poor outcomes in trauma patients during acute phases. The aim of our study is to evaluate the effect of hypothermia on admission, upon in-hospital complications and mortality in adult trauma patients.MethodsWe performed a 5-year analysis of ACS-TQIP database (2017-2021). Patients with incomplete data, burns, inter-facility transfers, or documented as dead on arrival were excluded. Hypothermia (HT) was defined as a temperature of <35 degrees Celsius (°C), and Normothermia (NT) as ≥35 °C to≤40 °C measured at the time of patient arrival. Data were collected including demographic variables, mechanism of injury, injury severity, injury patterns, and shock index. Outcome variables were mortality, ICU length of stay (LOS), duration of mechanical ventilation, hospital LOS, and in-hospital complications. Multivariable regression analysis was performed.ResultsA total of 3,043,030 patients were included and 1 % were hypothermic. HT patients were severely injured, developed in-hospital complications (17.1 %vs.4.5 %), had longer ICU LOS (4 (2-9) vs. 3 (2-5) days), hospital LOS (5 (2-12) vs. 4 (2-6) days), and higher mortality (23.4 % vs. 2.3 %). Hypothermia was independently associated with higher odds of mortality (OR:1.934 [1.858-2.013]). Subgroup analysis of patients with isolated traumatic brain injury revealed pre-hospital hypothermia to still be an independent predictor of mortality (OR: 1.728[1.600-1.867]). HT who underwent rewarming had a lower mortality, shorter hospital and ICU LOS.ConclusionPre-hospital hypothermia is independently associated with higher resource utilization, in-hospital complications, and mortality. Even in patients with isolated TBI, pre-hospital hypothermia increases the odds of mortality. Rewarming interventions can potentially improve outcomes among patients, even with mild hypothermia.Level Of EvidenceLevel III retrospective study.Copyright © 2024. Published by Elsevier Ltd.

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