• World Neurosurg · Dec 2024

    Review

    Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery.

    • Nicholas J Erickson, Mihaela Stavarache, Tekedereli Ibrahim, Michael G Kaplitt, and James M Markert.
    • Department of Neurological Surgery, the University of Alabama at Birmingham, Birmingham, AL, USA.
    • World Neurosurg. 2024 Dec 20: 123595123595.

    AbstractThe authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood brain and blood tumor barrier in a safe and effective manner.Copyright © 2024. Published by Elsevier Inc.

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