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Randomized Controlled Trial Multicenter Study Clinical Trial
LDL-C goal attainment with the addition of ezetimibe to ongoing simvastatin treatment in coronary heart disease patients with hypercholesterolemia.
- C Brohet, S Banai, A M W Alings, R Massaad, M J Davies, and C Allen.
- Saint-Luc Hospital-Catholic University of Louvain, Brussels, Belgium. brohet@card.ucl.ac.be
- Curr Med Res Opin. 2005 Apr 1; 21 (4): 571578571-8.
ObjectiveTo evaluate the addition of ezetimibe or placebo to on-going simvastatin treatment on attaining the LDL-C treatment target of MethodsPatients with documented CHD were recruited if they were on a stable dose of simvastatin 10 mg or 20 mg for at least 6 weeks, had LDL-C > 2.60 mmol/L and 100 mg/dL and ResultsWhen ezetimibe was added to on-going simvastatin therapy, a significantly greater percentage of patients attained the LDL-C target of ConclusionsEzetimibe co-administered with on-going simvastatin 10 mg or 20 mg treatment enabled more CHD patients with hypercholesterolemia to attain the LDL-C treatment target of
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