• A R Folsom, S A Kaye, T A Sellers, C P Hong, J R Cerhan, J D Potter, and R J Prineas.
• Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1105.
• JAMA. 1993 Jan 27; 269 (4): 483487483-7.

ObjectiveTo test the hypothesis that both body mass index (expressed as the ratio of weight in kilograms per height in meters squared) and the ratio of waist circumference to hip circumference are positively associated with mortality risk in older women.DesignProspective cohort study with a 5-year follow-up period.SettingGeneral community.ParticipantsRandom sample of 41,837 Iowa women aged 55 to 69 years.Main Outcome MeasureTotal mortality (1504 deaths).Main ResultsBody mass index, an index of relative weight, was associated with mortality in a J-shaped fashion: rates were elevated in the leanest as well as in the most obese women. In contrast, waist/hip circumference ratio was strongly and positively associated with mortality in a dose-response manner. Adjusted for age, body mass index, smoking, education level, marital status, estrogen use, and alcohol use, a 0.15-unit increase in waist/hip circumference ratio (eg, a 15-cm [6-in] increase in waist measurement in a woman with 100-cm [40-in] hips) was associated with a 60% greater relative risk of death. The observed associations were not explained to any great degree by bias from weight loss prior to baseline or higher early deaths among lean participants.ConclusionsWaist/hip circumference ratio is a better marker than body mass index of risk of death in older women. Waist/hip circumference ratio should be measured as part of routine surveillance and risk monitoring in medical practice.

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