• Ye Rin Koh, Yufei Li, Joan Koh, Elyad Ekrami, Xiaodan Liu, Maged Y Argalious, Mariel R Manlapaz, Christopher A Troianos, Michael P Steinmetz, and Ehab Farag.
• From the Department of Anesthesiology, Cleveland Clinic, Cleveland, Ohio.
• Anesth. Analg. 2024 Dec 17.

BackgroundBoth intraoperative hypotension and excessive fluid administration can lead to detrimental perioperative complications. However, how much fluid is considered excessive and how is intraoperative hypotension related to major postoperative complications?MethodsWe conducted a single-center retrospective cohort study in 6243 patients undergoing complex spine surgery at the Cleveland Clinic Foundation between 2012 and 2022 and studied the relationship between intraoperative net fluid administration and intraoperative hypotension with major postoperative complications. The primary outcome was a collapsed composite of postoperative complications including acute kidney injury (AKI), myocardial infarction (MI), stroke, and intensive care unit (ICU) admissions. Secondary outcomes were in-hospital postoperative pulmonary complications, surgical site infections (SSI), and mortality.ResultsThe study consisted of 6998 complex spinal surgery cases from 6243 patients. The median net fluid administration was 2100 mL (Interquartile range: 1450 to 3020 mL), and we found a change point in net fluid administration of 1865 mL (95% Confidence Interval: 1228 to 4710 mL). The odds ratio of developing postoperative complications for every 500 mL increase in net fluid administration was 1.16 (95% confidence interval [CI], 1.11-1.21; P < .0001) above and 0.87 (95% CI, 0.77-0.98; P = .026) below the change point. The odds ratio of developing postoperative pulmonary complications was 1.12 (95% CI, 1.07-1.18; P < .0001) for every 500 mL increase in net fluid administration.Intraoperative hypotension was detected in 2052 complex spine surgeries (29%). The odds ratio of developing any postoperative complication was 1.57 (95% CI, 1.37-1.80; P < .0001) and 1.30 (95% CI, 1.04-1.61; P = .019) for postoperative pulmonary complications.ConclusionsWe discovered a change point in net fluid administration of 1,865mL. Above this change point, higher net fluid administration is associated with increased odds of developing postoperative complications. Intraoperative hypotension in complex spine surgeries was associated with increased postoperative complications.Copyright © 2024 International Anesthesia Research Society.

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