• Lancet · Apr 1985

    Renal failure and the use of morphine in intensive care.

    • M Ball, H J McQuay, R A Moore, M C Allen, A Fisher, and J Sear.
    • Lancet. 1985 Apr 6; 1 (8432): 784786784-6.

    AbstractIntravenous morphine infusions were given to 20 patients in the intensive-care unit to provide sedation and analgesia. In 10 of the patients renal impairment was already present or developed during intensive care. Plasma morphine concentrations for a given dose of morphine and morphine clearance depended on renal function; dose-related plasma morphine concentrations rose as renal function deteriorated. Reduced morphine clearance leads to increased elimination half-life of the drug, and neurological impairment caused by unrecognised high concentrations of morphine could result in an incorrect diagnosis of cerebral damage in patients in intensive care.

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