• Kamal Sud, Sundararaman Swaminathan, Neelam Varma, Harbir Singh Kohli, Vivekanand Jha, Krishan Lal Gupta, and Vinay Sakhuja.
• Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
• Nephrology (Carlton). 2004 Dec 1;9(6):422-5.

AbstractCombined liver and kidney transplantation is the ideal treatment for patients with end-stage renal failure secondary to primary hyperoxaluria and systemic oxalosis, with a functioning liver providing replacement of the deficient enzyme and a functioning kidney providing the route of excretion for the oxalate crystals. Pancytopenia from bone marrow infiltration of oxalate crystals is a rare complication of primary hyperoxaluria, and its reversal following transplant has not been described. We report the first case of pancytopenia from marrow infiltration by oxalate crystals reversing following a successful kidney transplant alone. Although kidney alone transplants do not provide the best chance of survival or quality of life as compared to a combined kidney and liver transplant, a well functioning kidney transplant is able to take care of the systemic oxalate load and ameliorate, at least for a period of time, the systemic complications of oxalosis.

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