• Med Klin · Jul 1997

    Review

    [High dose chemotherapy of solid tumors].

    • K Höffken, R Kath, H J Fricke, K Blumenstengel, W Vogel, and H G Sayer.
    • Klinik und Poliklinik für Innere Medizin II (Onkologie, Hämatologie, Endokrinologie, Stoffwechselerkrankungen). Friedrich-Schiller-Universität Jena.
    • Med Klin. 1997 Jul 15; 92 (7): 410414410-4.

    BackgroundThe availability of hemopoetic growth factors and the retransfusion of autologous peripheral blood stem cells (PBSC) have enabled high-dose chemotherapy (HDT) options for the treatment of advanced solid tumours, during recent years. Though the transfusion of PBSC can manage the myelosuppression, dose-escalation ist still limited by non-haematological toxicity.MethodUsually, HDT has been given after a proceeding dose-intense chemotherapy that allowed the evaluation of chemosensitivity of the disease and resulted in a stem cell mobilization into the peripheral blood. The autologous bone marrow transplantation has almost completely been replaced by retransfusion of PBSC together with hemopoietic growth factors as specific supportive treatment. The PBSC are harvested by apheresis using a blood cell separator.ResultsResults on the efficacy of HDT are available for breast, testicular, ovarian, small cell lung cancer as well as melanoma, glioblastoma and soft-tissue sarcoma. The studies showed the feasibility and efficacy of HDT with tolerable toxicity.ConclusionHigh-dose chemotherapy will be of increasing importance in the treatment strategies of primary solid tumors, in the near future.

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