• J. Korean Med. Sci. · Dec 2024

    Multicenter Study

    Characteristics of Pediatric Ulcerative Colitis at Diagnosis in Korea: Results From a Multicenter, Registry-Based, Inception Cohort Study.

    • Jin Gyu Lim, Ben Kang, Seak Hee Oh, Eell Ryoo, Yu Bin Kim, Yon Ho Choe, Yeoun Joo Lee, Minsoo Shin, Hye Ran Yang, Soon Chul Kim, Yoo Min Lee, Hong Koh, Ji Sook Park, So Yoon Choi, Su Jin Jeong, Yoon Lee, Ju Young Chang, Tae Hyeong Kim, Jung Ok Shim, and Jin Soo Moon.
    • Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
    • J. Korean Med. Sci. 2024 Dec 23; 39 (49): e303e303.

    BackgroundWe aimed to investigate the characteristics of pediatric ulcerative colitis (UC) at diagnosis in Korea.MethodsThis was a multicenter, registry-based, inception cohort study conducted in Korea between 2021 and 2023. Children and adolescents newly diagnosed with UC < 18 years were included. Baseline clinicodemographics, results from laboratory, endoscopic exams, and Paris classification factors were collected, and associations between factors at diagnosis were investigated.ResultsA total 205 patients with UC were included. Male-to-female ratio was 1.59:1, and the median age at diagnosis was 14.7 years (interquartile range 11.9-16.2). Disease extent of E1 comprised 12.2% (25/205), E2 24.9% (51/205), E3 11.2% (23/205), and E4 51.7% (106/205) of the patients. S1 comprised 13.7% (28/205) of the patients. The proportion of patients with a disease severity of S1 was significantly higher in patients with E4 compared to the other groups (E1: 0% vs. E2: 2% vs. E3: 0% vs. E4: 24.5%, P < 0.001). Significant differences between disease extent groups were also observed in Pediatric Ulcerative Colitis Activity Index (median 25 vs. 35 vs. 40 vs. 45, respectively, P < 0.001), hemoglobin (median 13.5 vs. 13.2 vs. 11.6 vs. 11.4 g/dL, respectively, P < 0.001), platelet count (median 301 vs. 324 vs. 372 vs. 377 × 10³/μL, respectively, P = 0.001), C-reactive protein (median 0.05 vs. 0.10 vs. 0.17 vs. 0.38 mg/dL, respectively, P < 0.001), and Ulcerative Colitis Endoscopic Index of Severity (median 4 vs. 4 vs. 4 vs. 5, respectively, P = 0.006). No significant differences were observed in factors between groups divided according to sex and diagnosis age.ConclusionThis study represents the largest multicenter pediatric inflammatory bowel disease cohort in Korea. Disease severity was associated with disease extent in pediatric patients with UC at diagnosis.Trial RegistrationClinical Research Information Service Identifier: KCT0008723.© 2024 The Korean Academy of Medical Sciences.

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