• Nadya Vinsdata, Robert E Heidel, and Paul J Hauptman.
• the University of Nevada, Reno School of Medicine, Reno, NV.
• Am. J. Med. 2025 Jan 2.

BackgroundA wide array of products in the category of complementary or alternative medicine products for cardiovascular disease and prevention are readily available on online retail platforms. However, a critical assessment of these products including their therapeutic claims has not been previously performed.Methods"Heart failure supplement" and similar terms were entered into the Amazon.com search engine and all medication products including claims, content and formulations were individually evaluated.ResultsWe identified 111 products, most of which lack safety information; include on average 8.2 ingredients; and cost $27.60 per order (median). Most were in capsule form (58.6%) and the most common ingredient was Co-Enzyme Q10. All included a legal disclaimer; physician testimonials were included in only 3 product listings.ConclusionsGiven the popularity of and easy accessibility to online retailing of complementary and alternative medicine and the fact that prior studies suggest a minority of patients discuss use with their providers, further study is needed to evaluate the extent of use and the potential for both undiagnosed drug-drug interactions and/or replacement of guideline-directed medical treatment for heart failure with unapproved products.Copyright © 2025. Published by Elsevier Inc.

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