• Louise Breum Petersen, Søren Bie Bogh, Peter Martin Hansen, Louise Milling, Jens Stubager Knudsen, Helena Pedersen, Erika F Christensen, Ulla Væggemose, Fredrik Folke, Signe Amalie Wolthers, ChristensenHelle CollatzHCDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Prehospital Centre, University of Copenhagen, Naestved, Denmark. Electronic address: hcli@regionsjaelland.dk., Anne Craveiro Brøchner, and Søren Mikkelsen.
• Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark; The Prehospital Research Unit, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark. Electronic address: Louise.Breum.Petersen@rsyd.dk.
• Resuscitation. 2024 Dec 5; 206: 110454110454.

BackgroundThe guidelines for Advanced Life Support issued by the European Resuscitation Council recommend considering drug delivery through intraosseous access if intravenous access to the vascular bed is not feasible or unsuccessful. Emergency prehospital intraosseous cannulation may theoretically lead to an increased risk of long-term complications such as osteomyelitis, osteonecrosis, or compartment syndrome. Such complications have previously been reported in case reports or small sample case series. We systematically investigated long-term complications potentially associated with intraosseous cannulation using validated Danish health registries.MethodsData sources were the nationwide electronic Prehospital Patient Record system, the Danish National Patient Registry, and the Danish Civil Personal Registry. We investigated all patients who were subjected to prehospital intraosseous cannulation in Denmark from January 2016 through December 2019. During a follow-up period of 180 days from the index date we extracted information concerning mortality status and potential long-term complications defined as osteomyelitis, osteonecrosis, or compartment syndrome from the day of prehospital intraosseous cannulation.ResultsOf the 5,387 patients receiving intraosseous access, 375 were unidentified and lost to follow-up. Of the 5012 remaining patients, 4,775 were adults, and 237 were children. No children and "less than five" adults had long-term complications. No osteonecrosis, osteomyelitis or compartment syndrome appeared later than 175 days after an intraosseous cannulation.ConclusionsLong-term complications such as osteomyelitis, osteonecrosis, or compartment syndrome following prehospital intraosseous cannulation and drug delivery occurred in less than 0.1% of the cases. Our findings indicate that prehospital intraosseous cannulation may be safe across age groups.Copyright © 2024. Published by Elsevier B.V.

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