• Weifeng Ma, Rui Guo, and Wei Hu.
• Department of Orthopaedic Surgery, the Bozhou Hospital Affiliated to Anhui Medical University, Bozhou, Anhui, China.
• World Neurosurg. 2025 Jan 6: 123648123648.

BackgroundAcute spinal cord injury causes severe motor and sensory dysfunction, significantly burdening individuals and society. This study uses bibliometric analysis to identify research trends and key areas, providing insights for future advancements in treatment.MethodsScientific publications on acute spinal cord injury were collected from PubMed and the Web of Science Core Collection (WoSCC) between 2000 and 2022. Data were analyzed using Bibliometric, CiteSpace, and BICOMB, with gCLUTO applied for co-word bicluster analysis based on MeSH term matrices.Results2,513 publications on acute spinal cord injury were published, with the number of articles increasing annually from 38 to 268. Spinal Cord has emerged as the leading journal in this field, and the United States maintains its dominant position in global research impact. The University of Toronto ranks first among research institutions, with significant contributions from researchers such as Fehlings and Kwon. Research on acute spinal cord injury primarily focuses on seven key areas: metabolism, pharmacology, surgical timing, rehabilitation, pathology, clinical predictors, and diagnostic imaging.ConclusionsOur study reveals substantial growth in acute spinal cord injury research over the past two decades, emphasizing leading countries, researchers, institutions, and journals. Animal models remain pivotal in drug development for basic medicine and neuroscience. Consensus has been reached among experts regarding the timing of surgical intervention, while artificial intelligence and multidisciplinary approaches are emerging as promising avenues for comprehensive treatment. Additionally, Ongoing research into spinal cord injury pathophysiology provides essential guidance for pharmacological and surgical treatments.Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.

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