• Rong Liufu, Yan Chen, Jing-Yi Wang, Yang-Yan-Qiu Wang, Yao Wu, Wei Jiang, Chun-Yao Wang, Jin-Min Peng, Li Weng, and Bin Du.
• Medical ICU, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
• Crit. Care Med. 2024 Nov 15.

ObjectivesThis study aimed to investigate the relationship between ABO blood group and sepsis-associated thrombocytopenia (SAT).Design And SettingThe primary outcome was SAT within the first 72 hours of ICU admission.PatientsThe retrospective study included 9113 patients diagnosed with sepsis from January 2014 to December 2022. A total of 6296 patients eventually were included into the study, who were divided into four groups based on ABO blood group.InterventionsNone.Measurements And Main ResultsA total of 2494 patients (39.6%) were diagnosed with SAT, and 712 (11.3%) of them experiencing severe SAT. The occurrence of SAT among the ABO blood groups was significantly lower in AB blood group compared with the other groups (p = 0.032). Individuals in AB blood group were less likely to experience severe SAT (p = 0.028). In multivariate analysis, B blood group (odds ratio [OR], 1.32; 95% CI, 1.05-1.67) and O (OR, 1.37; 95% CI, 1.09-1.72) were significantly associated with a higher occurrence of SAT compared with AB blood group. In multivariate analyses, A blood group (OR, 1.68; 95% CI, 1.16-2.42), B blood group (OR, 1.74; 95% CI, 1.74-2.50), and O blood group (OR, 1.72; 95% CI, 1.20-2.48) remained significantly risk factors associated with a higher occurrence of severe SAT compared with AB blood group.ConclusionsB blood group and O were associated with an increased risk of SAT and severe SAT.Copyright © 2024 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.

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