• Curr Pain Headache Rep · Jan 2025

    Review

    Dialysis Headache: An Updated Literature Review.

    • Mark Barber.
    • The David S. and Ruth L. Gottesman Center for Headache Treatment and Translational Research at the Icahn School of Medicine at Mount Sinai, 5 East 98th Street, 7th Floor, New York, NY, 10029, USA. mark.barber2@mountsinai.org.
    • Curr Pain Headache Rep. 2025 Jan 8; 29 (1): 1616.

    Purpose Of ReviewThe objective of this review is to describe recent updates in the understanding of dialysis headache. These recent findings will be placed in a historical context that reviews the clinical features, classification, epidemiology, pathophysiology, and treatment of dialysis headache.Recent FindingsThere is something intrinsic to the dialysis procedure itself that leads to headaches in susceptible individuals. Proposed mechanisms include fluid and electrolyte shifts, blood pressure parameters, the release of neuroinflammatory particles, and the mechanics of the dialysis procedure. Recent findings quantify the potential roles of CGRP and substance P in dialysis headache pathophysiology. Advances in dialysis techniques, like online hemodiafiltration, have also been found to vastly reduce headache incidence. Caffeine, which has anecdotally been considered potentially therapeutic for dialysis headache, may not actually provide benefit. Dialysis headache significantly impairs quality of life in many individuals on hemodialysis, a procedure which is itself already burdensome. A clearer understanding of the pathophysiology of dialysis headache has the potential to drive therapeutic advances.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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