• Yahya Kaan Karatepe, Ugur Kesici, Mehmet Güray Duman, Mahmut Salih Genç, Kubra Bozali, Eray Metin Guler, Ayşe Gökçen Sade, and Sibel Oba.
• Department of General Surgery, Malatya Battalgazi State Hospital, Malatya-Türkiye.
• Ulus Travma Acil Cerrahi Derg. 2025 Jan 1; 31 (1): 181-8.

BackgroundIntraabdominal adhesions increase the incidence and length of surgical complications. Many anti-adhesive agents have been used for this purpose, but no definitive solution has yet been found. Studies on the prevention and reduction of anastomotic leakage, therefore, remain up to date. This study aimed to determine the effects of Rosmarinus Officinalis extract on colon anastomosis as a surgical model, its antiadhesive activity, and its impact on wound healing in the laparotomy site simultaneously to facilitate the clinical application of Rosmarinus Officinalis extract.MethodsThe rats were divided into two groups of seven rats each. Group C (Control): Laparotomy with colon anastomosis + 2 mL isotonic solution. Group R (Rosmarinus officinalis): Laparotomy + colon anastomosis, + 2 mL of 2% rosmarinus officinalis. Macroscopic adhesion scoring was performed and recorded. The tensile strength of the wound was assessed using tissue samples obtained from the incision line. From the incision line, tissue samples were obtained for histopathological investigation and tissue hydroxyproline levels. Anastomotic burst pressure was measured from the segment of colon anastomosis.ResultsIn terms of Macroscopic adhesion score, there was no statistically significant difference between Group C and Group R (p=1.000). The mean Wound tensile strength value of Group R was significantly lower than that of Group C (p=0.003). In terms of mean Anastomotic burst pressure, there was no statistically significant difference between Group C and Group R (p=0.078).ConclusionAccording to the findings of our investigation, peritoneal administration of Rosmarinus Officinalis extract in the early postoperative period may increase the risk of evisceration in the abdominal incision site.

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