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- Tomoko Tadokoro, Joji Tani, Yudai Sato, Rie Yano, Kei Takuma, Mai Nakahara, Kyoko Oura, Koji Fujita, Masafumi Ono, Atsushi Tobiume, Seisuke Sato, Takuya Inoue, Asahiro Morishita, and Hideki Kobara.
- Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
- Intern. Med. 2025 Jan 3.
AbstractA 32-year-old man presented with cirrhosis. At 8 years of age, he underwent resection of a craniopharyngioma, which resulted in panhypopituitarism. He underwent self-interrupted hormone replacement therapy at 20 years of age. Computed tomography revealed severe fatty liver and cirrhosis. An endocrinological evaluation revealed panhypopituitarism. Further assessment revealed a diagnosis of hepatopulmonary syndrome. Home oxygen therapy and hormone replacement therapy were initiated. Despite these efforts, poorly controlled hypothalamic obesity led to liver failure, and the patient is currently awaiting liver transplantation. Liver cirrhosis associated with long-term panhypopituitarism may have a poor prognosis even with hormone replacement therapy.
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