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- Takahiro Osuga, Tomohiro Kubo, Koji Miyanishi, Ryo Ito, Taro Sugawara, Hiroyuki Ohnuma, Kazuyuki Murase, and Kohichi Takada.
- Department of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
- Intern. Med. 2025 Jan 3.
AbstractA 65-year-old man with hepatocellular carcinoma and lung metastasis was treated with a combination of atezolizumab and bevacizumab. Subsequently, the patient developed fever and new liver lesions, which were considered to indicate a pseudoprogression. Despite this, the treatment was continued. Three months later, CT scans demonstrated that the new lesions had disappeared and both the primary tumor and metastases had shrunk. A partial response was achieved and maintained for two years. A histological examination revealed a predominance of CD8-positive lymphocytes and PD-L1-positive tumor-associated macrophages, which may predict a positive response to this therapy. Pseudoprogression may therefore be a favorable prognostic factor in hepatocellular carcinoma.
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