• Sekar Loganathan, Kamal Kajal, Kashish Garg, Sameer Sethi, Deepesh B Kenwar, Amit Sharma, Ashish Aditya, Varun Mahajan, Naveen B Naik, and Rajnikant Kumar.
• Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
• BMC Anesthesiol. 2025 Jan 8; 25 (1): 1313.

BackgroundPostoperative pain remains a significant problem in patients undergoing donor nephrectomy despite reduced tissue trauma following laparoscopic living donor nephrectomy (LLDN). Inadequately treated pain leads to physiological and psychological consequences, including chronic neuropathic pain.Materials And MethodsThis randomized controlled double-blinded trial was conducted in sixty-nine (n = 69) participants who underwent LLDN under general anesthesia. Participants were randomized into Group B (n = 34) and Group C (n = 35). Group B received ultrasound-guided bilateral erector spinae plane block (ESPB) with bupivacaine 0.125% 20 ml on the surgical side and 10 ml on the contralateral side before extubation, while Group C received wound infiltration with bupivacaine 0.125% 15 ml. The primary objective of the study was to compare cumulative 24-hour morphine consumption postoperatively. The secondary objectives were time to first rescue analgesia, visual numeric rating scale (VNRS) pain scores at rest and during movement, incidence of postoperative nausea and vomiting (PONV), and complications associated with ESPB.ResultsParticipants in Group B required significantly less median (IQR) 24-hour morphine compared to Group C [6 (6-9) mg vs. 15 (12-15) mg; median difference 9; 95% CI in median difference 6-12; p < 0.001), longer median (IQR) time to first rescue analgesia [6 (6-8) hours vs. 1 (1-2) hours; p < 0.001], and lower VNRS at rest and during movement at baseline, 0.5, 1, 2, 4, 6, 8, 12, 24 hours.ConclusionUltrasound-guided ESPB provided effective pain relief compared to wound infiltration with local anaesthetic in patients who underwent LLDN.Trial RegistrationINT/IEC/2021/SPL-514; CTRI/2021/07/045909.© 2025. The Author(s).

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