• The lancet oncology · Jan 2025

    Review

    Advances and challenges in precision imaging.

    • Hedvig Hricak, Marius E Mayerhoefer, Ken Herrmann, Jason S Lewis, Martin G Pomper, Christopher P Hess, Katrine Riklund, Andrew M Scott, and Ralph Weissleder.
    • Department of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Lancet Oncol. 2025 Jan 1; 26 (1): e34e45e34-e45.

    AbstractTechnological innovations in genomics and related fields have facilitated large sequencing efforts, supported new biological discoveries in cancer, and spawned an era of liquid biopsy biomarkers. Despite these advances, precision oncology has practical constraints, partly related to cancer's biological diversity and spatial and temporal complexity. Advanced imaging technologies are being developed to address some of the current limitations in early detection, treatment selection and planning, drug delivery, and therapeutic response, as well as difficulties posed by drug resistance, drug toxicity, disease monitoring, and metastatic evolution. We discuss key areas of advanced imaging for improving cancer outcomes and survival. Finally, we discuss practical challenges to the broader adoption of precision imaging in the clinic and the need for a robust translational infrastructure.Copyright © 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.

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