• Am. J. Med. Sci. · Jan 2025

    Review

    Carcinogenetic mechanisms employed by the oral microbiome: a narrative review.

    • Sanjay V Menghani.
    • University of Arizona College of Medicine - Tucson, AZ, USA; Medical Scientist Training MD-PhD Program, University of Arizona College of Medicine Tucson, AZ, USA. Electronic address: sanjaymenghani@arizona.edu.
    • Am. J. Med. Sci. 2025 Jan 7.

    AbstractCancers of the oral cavity, lip, salivary gland, and oropharynx cause substantial global disease burden. While tobacco-use and alcohol use are highly associated with oral cancers, the rising incidence of disease in patients who do not use tobacco or alcohol points to additional carcinogenic risk factors. Chronic inflammation, disruption of the oral microbiome, and dysbiosis are becoming more widely implicated in the pathogenesis of oral cancer. Several studies have identified specific bacterial species enriched in patients with oral cancer, including Porphyromonas gingivalis and Fusobacterium nucleatum. In this narrative review, we describe potential carcinogenic mechanisms exhibited by these species and other microbes in the development of oral cancer.Copyright © 2025. Published by Elsevier Inc.

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