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Revista médica de Chile · May 2024
Multicenter Study[Tacrolimus in Difficult to Treat Proteinuria Associated with Lupus Nephritis. Experience of 3 Centers].
- Cristóbal Oyarzún, Sonia Arriagada, Lorena Soto, Leonidas Llanos, and Andrea Bancalari.
- Hospital Base San José, Universidad Austral de Chile, Valdivia, Chile.
- Rev Med Chil. 2024 May 1; 152 (5): 589595589-595.
UnlabelledThe management of proteinuria in patients with lupus nephritis represents a challenge for the specialist. Recently, Calcineurin Inhibitors have been positioned as an effective alternative in these patients, but their use is not widespread in our country. We report the experience of three centers in this regard.Methodsa review of lupus nephritis patients treated with Tacrolimus from 3 centers in southern Chile.ResultsData from 10 patients with Lupus nephritis were obtained. All of them had significant proteinuria after the traditional induction scheme. In most of them, there was a significant decrease in proteinuria without deterioration of creatinine at 12 months after treatment with Tacrolimus alone or in combination with Mycophenolate.ConclusionsTacrolimus alone or in combination with Mycophenolate is a safe and effective alternative in the management of Lupus nephritis-associated proteinuria.
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