• Karine Brousseau, Leah Monette, Daniel I McIsaac, Christopher Wherrett, Ranjeeta Mallick, Aklile Workneh, Tim Ramsay, Alan Tinmouth, Julie Shaw, Justin Presseau, Julie Hallet, François M Carrier, Dean A Fergusson, and Guillaume Martel.
• Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
• Br J Anaesth. 2025 Feb 1; 134 (2): 341349341-349.

BackgroundPoint-of-care testing devices to measure haemoglobin (Hgb) frequently inform transfusion decision-making in surgery. This study aimed to examine their accuracy in surgery, focusing on Hgb concentrations of 60-100 g L-1, a range with higher potential for transfusion.MethodsThis was a prospective diagnostic cohort study focused on method comparison, conducted at two academic hospitals. Consecutive patients undergoing noncardiac surgery and requiring point-of-care Hgb measurements were eligible. Hgb concentrations from arterial and central venous blood samples were measured concurrently using three devices and compared with laboratory Hgb. The primary outcome was individual pairwise comparisons between point-of-care and laboratory Hgb values; agreement was determined based on a threshold of within 4 g L-1. The primary analysis consisted of computing limits of agreement.ResultsA total of 1735 intraoperative blood samples were collected (1139 participants); 680 samples had a laboratory Hgb <100 g L-1. The limits of agreement among those with Hgb <100 g L-1 were -9.5 to 8.0 g L-1 for HemoCue®, -16.2 to 11.5 g L-1 for i-STAT®, and -14.7 to 40.5 g L-1 for Rad-67®. HemoCue was associated with a 5.8% incidence of potentially clinically significant transfusion error, whereas i-STAT and Rad-67 were associated with 25.3% and 28.2%, respectively. HemoCue yielded Hgb measurements within 10 g L-1 in 98% of intraoperative blood samples.ConclusionsNo point-of-care Hgb device demonstrated limits of agreement that were smaller than the agreement difference of 4 g L-1. Despite this, HemoCue can be safely used to inform transfusion decisions in surgery, given its error probability of <4% in transfusion scenarios.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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