• Li-Wen Su, Huan Sun, Hong-Yu Zhang, and Yang Wu.
• Department of Oral and Maxillofacial Surgery.
• Medicine (Baltimore). 2025 Jan 10; 104 (2): e41231e41231.

RationaleWhen gland-preserving treatments are unsuccessful, sialoadenectomy is typically conducted for patients afflicted with submandibular gland diseases. The definitive treatment modality for these individuals is the removal of both the gland and the associated ducts. During surgery, the gland and the majority of the ducts can be excised utilizing the lateral transcervical approach, with residual ducts unlikely to develop pathology. After sialoadenectomy, the recurrence of salivary gland stones is extremely rare. Although there are some relevant speculations, to the best of our knowledge, there are no comprehensive reports of larger recurrent stone-related cases available.Patient ConcernsWe present 2 instances of recurrent sialoliths in the residual Wharton duct following sialoadenectomy. In our cases, it was not until several years later that both patients presented with symptoms. The patients, a 51-year-old male and a 28-year-old female, presented with swelling and purulent discharge in the right floor of the mouth.DiagnosesComputed tomography scans revealed irregular high-density masses in the floor of the mouth, indicative of sialolithiasis.InterventionsThe intraoral incision exposed the recurrent sialoliths, which were successfully removed along with the residual duct.OutcomesThere were no complications in both cases.LessonsThis report aims to clarify potential mechanisms behind recurrent sialoliths in residual Wharton ducts after submandibular gland excision, warranting further investigation to improve patient management. New stones may form again in the residual duct even if the glands were removed. With the risk of recurrent sialoliths after resection of the gland, multiway preventive management can optimize outcomes.Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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