• Xun Li, Yang Lv, Yu Xia, Yulian Lai, Shangbin Chen, Yinzi Xie, Ziwei Tang, and Qingfeng Cheng.
• Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
• Medicine (Baltimore). 2025 Jan 10; 104 (2): e41168e41168.

RationalePeliosis hepatis (PH) is a rare disease with few clinical reports and complex etiology. However, there have been no reports of hyperprolactinemia (HPRL) leading to PH at present. This paper, through case reports, expands the understanding of the etiology of PH and the pathological damage effect of prolactin (PRL).Patient ConcernsThe patient reported in this paper had jaundice, menstrual disorders, menopause, weight gain, and other symptoms. Laboratory examination found increased levels of PRL and transaminase in liver function, and imaging examination indicated pituitary tumor and PH.DiagnosesComprehensive patient history and auxiliary examination, the clinical diagnosis was pituitary PRL tumor and PH.Interventions And OutcomesAfter treatment with bromocriptine, menstruation recovered and liver function returned to normal. In addition, the follow-up imaging examination indicated that pituitary tumors and PH lesions were shrinking, and clinical phenomena indicated that HPRL caused by pituitary prolactinoma was correlated with PH occurrence.LessonsSince there is no report of HPRL causing PH, the specific pathogenesis is unknown. This paper reviews the relevant literature and puts forward the theoretical consideration of the pathogenesis. Through this case, for clinically similar patients, it is warned that we need to consider the possibility of PH and further improve the examination, evaluation and treatment in time.Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

20 keywords...

hide…