• Medicine · Jan 2025

    Case Reports

    Disseminated organ and tissue infection secondary to carbapenem-resistant Klebsiella pneumoniae bloodstream infection for acute lymphoblastic leukemia treated with ceftazidime-avibactam: Two case reports.

    • Mingxia He, Yuxia Jiang, Haiying Wu, Xiaofeng Xu, and Huifang Jiang.
    • Department of Hematology, Tongde Hospital of Zhejiang Province, Hangzhou, P.R. China.
    • Medicine (Baltimore). 2025 Jan 10; 104 (2): e41195e41195.

    RationaleCarbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infections are a severe complication resulting from granulocyte deficiency following chemotherapy for hematologic malignancies and have a high mortality rate. However, reports of disseminated organ infections secondary to bloodstream infections are rare.Patient Concerns And DiagnosesWe report 2 cases of patients with acute lymphoblastic leukemia who both developed CRKP bloodstream infections during the granulocyte deficiency stage following chemotherapy, with 1 case of secondary bacterial liver abscess and 1 case of secondary septic arthritis.Interventions And OutcomesBased on the results of drug sensitivity testing, both patients were treated with ceftazidime-avibactam, and the infections were rapidly and effectively controlled without significant adverse effects.LessonsCeftazidime-avibactam exhibited satisfactory efficacy and safety in the 2 cases of disseminated organ infection secondary to CRKP bloodstream infection following chemotherapy for acute lymphoblastic leukemia.Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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