• J. Korean Med. Sci. · Jan 2025

    Etiology and Clinical Prediction of Community-Acquired Lower Respiratory Tract Infection in Children.

    • Byungsun Yoo, Ilha Yune, Dayeon Kang, Youngmin Cho, Sung Yoon Lim, Sooyoung Yoo, Miyoung Kim, June Sung Kim, Daehwan Kim, Ho Young Lee, Rong-Min Baek, Se Young Jung, Eu Suk Kim, and Hyunju Lee.
    • Department of Pediatrics, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam, Korea.
    • J. Korean Med. Sci. 2025 Jan 13; 40 (2): e5e5.

    BackgroundCommunity acquired lower respiratory tract infection (LRTI) is a leading cause for hospitalization in children and important cause for antibiotic prescription. We aimed to describe the aetiology of LRTI in children and analyse factors associated with bacterial or viral infection.MethodsPatients aged < 19 years with a diagnosis of LRTI were identified from the Observational Medical Outcomes Partnership Common Data Model Database of Seoul National University Bundang Hospital from January 2005-July 2019, and their clinical characteristics were obtained from the electronic medical records and retrospectively reviewed.ResultsAmong 5,924 cases of LRTI, 74.2% were pneumonia and 25.8% were bronchiolitis/bronchitis. Patients' median age was 1.8 (interquartile range, 3.1) years and 79.9% were < 5 years old. Pathogens were identified in 37.8%; 69.1% were viral and 30.9% were bacterial/Mycoplasma pneumoniae. Respiratory syncytial virus was most common (70.9%) among viruses and M. pneumoniae (94.6%) was most common among bacteria. Viral LRTI was associated with winter, age < 2 years, rhinorrhoea, dyspnoea, lymphocytosis, thrombocytosis, wheezing, stridor, chest retraction, and infiltration on imaging. Bacteria/M. pneumoniae LRTI was associated with summer, age ≥ 2 years, fever, decreased breathing sounds, leucocytosis, neutrophilia, C-reactive protein elevation, and positive imaging findings (consolidation, opacity, haziness, or pleural effusion).ConclusionIn children with LRTI, various factors associated with viral or bacterial/M. pneumoniae infections were identified, which may serve as guidance for antibiotic prescription.© 2025 The Korean Academy of Medical Sciences.

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