• Christian Wejse, Rikke Olesen, Paulo Rabna, Pernille Kaestel, Per Gustafson, Peter Aaby, Paul L Andersen, Henning Glerup, and Morten Sodemann.
• Bandim Health Project, INDEPTH Network, Statens Serum Institut, Bissau, Guinea-Bissau, University of Copenhagen, Copenhagen, Denmark. wejse@dadlnet.dk
• Am. J. Clin. Nutr. 2007 Nov 1;86(5):1376-83.

BackgroundLittle is known regarding vitamin D deficiency (VDD) in African populations and in tuberculosis (TB) patients. VDD has been shown to be associated with TB.ObjectiveWe aimed to compare the degree of vitamin D insufficiency (VDI) and VDD in TB patients and healthy adult controls in a West African population.DesignAn unmatched case-control study was performed at a Demographic Surveillance Site in Guinea-Bissau. Serum 25-hydroxyvitamin D(3) [25(OH)D(3)] concentrations were measured in 362 TB patients and in 494 controls.ResultsHypovitaminosis D [25(OH)D(3) ConclusionsHypovitaminosis D was highly prevalent in TB patients and in healthy controls living at 12 degrees N; severe VDD was rare in TB patients. The finding indicates that the serum 25(OH)D(3) concentration is associated with TB infection, but whether this role is a symptom or is causal was not established.

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